Aug 13, 2018 Common stimuli explored by stimuli-responsive polymers include endogenous [ e.g., reactive oxygen species (ROS), redox, pH, and enzymes] 

Spurred by recent progress in materials chemistry and drug delivery, stimuli-responsive devices that deliver a drug in spatial-, temporal- and dosage-controlled fashions have become possible.

Among the developed systems, stimuli-responsive dendrimers have shown great promise in drug delivery 4, 31, 33, 35-39. This review article will highlight novel strategies in the design of stimuli-responsive dendrimers, with emphasis on research in the past five years. Strategies adopted in the design of stimuli-responsive 2013-02-01 · Schematic exemplification of the drug release mechanism from a hydrogel stimuli-responsive electric delivery system. Adapted from Liu et al. [81], with permission of Elsevier.

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Spurred by recent progress in materials chemistry and drug delivery, stimuli-responsive devices that deliver a drug in spatial-, temporal- and dosage-controlled fashions have become possible. Implementation of such devices requires the use of biocompatible materials that are susceptible to a specifi … Pris: 1619 kr. Inbunden, 2018. Skickas inom 5-8 vardagar. Köp Stimuli-responsive Drug Delivery Systems av Amit Singh, Mansoor M Amiji på Bokus.com. pH-responsive systems take advantage of the significant variations in pH to stimulate localized drug delivery to different regions of the body such as the gastrointestinal tract, tumor microenvironment, or to the endosomal/lysosomal compartments of the cell (Figure 1). Stimuli-responsive drug-delivery nanocarriers (DDNs) have been increasingly reported in the literature as an alternative for breast cancer therapy.

Once a stimuli-responsive drug delivery system is subtly designed, loading the drug in the carrier could ideally achieve the on-demand release of the drug according to different environment of the disease/physiology or the dynamic process of the organism itself. Electro-responsive Systems Certain materials (organic and inorganic) exhibit conductive properties and can be used to design delivery systems that are responsive to an external electric field.

Traditional drug-delivery systems suffer some drawbacks, especially premature drug release and the lack of diverse stimuli responsiveness. The partnership between suitable solid support-based drug nanocarriers and supramolecular nanovalves led to a variety of gated materials containing supramolecular switches and polymers that are capable of targeted delivery and on-demand release of drugs

Very recently, the author has proposed a concept of environmental signal responsive chemical . The interaction of stimuli-sensitive polymers for tissue engineering and drug delivery with biosurfaces is critiqued, whilst the editor provides a skillful study into  Abstract : Hydrogels have successfully proved themselves useful for drug delivery applications and several delivery routes have been developed over the years.

Smart release stimuli via microencapsulation. Microparticles, microspheres, and microcapsules are widely used constituents of multiparticulate drug delivery 

Bob Langer gives an overview of many of these controlled drug release technologies. Purchase Stimuli Responsive Polymeric Nanocarriers for Drug Delivery Applications - 1st Edition. Print Book & E-Book.

Print Book & E-Book. ISBN 9780081019955, 9780081019962. Stimuli responsive drug delivery systems have emerged as one of the most innovative classes of polymer materials of modern materials science.
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2014 Informa Healthcare USA, Inc. DOI: 10.3109/10717544.2014.887157 CRITICAL REVIEW Classification of stimuli–responsive polymers as anticancer drug delivery systems Bita Taghizadeh1, Shahrouz Taranejoo2, Seyed Ali Monemian3, Zoha Salehi Moghaddam4, Karim Daliri5, Hossein Derakhshankhah6, and Zaynab The discussion goes from stimuli‐responsive polymers with responsive backbones or modified by responsive functional groups for drug encapsulation and release to polymer–drug conjugates with responsive covalent linkages. Intratumoral administration enables local drug delivery and low systemic toxicity.

The nanocarriers could accumulate and penetrate tumors, and target cancer cells for achieving different applications and functions by responding to the external and internal stimuli. (Click on the image to enlarge.) 2013-10-23 Stimuli-responsive materials, which exhibit changes in one or more properties in response to an external trigger, have gained interest due to their tunability and versatility. Our group has prepared stimuli-responsive materials including hydrogels, peptides, and nanoparticles for drug delivery applications.
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However, the MOF families and members, and the drug release mechanisms in MOF-based stimuli-responsive drug delivery systems (DDSs) are rarely summarized. Here, we systematically classified the families of MOF and introduced some representative members in MOF families.

Stimuli-responsive systems can roughly be Various advantages of hydrogels as drug delivery system come from their good transport properties, ability to protect drugs, proteins and peptides from the environment, bio- degradability and can be modified according to the route Stimuli-responsive hydrogels for intratumoral drug delivery. Ana C Marques UCIBIO, REQUIMTE, MEDTECH, Laboratory of Pharmaceutical Technology, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal. 2021-03-16 · Covalent organic frameworks (COFs) have received much attention in the biomedical area.

Among them, strategies utilizing stimuli‐responsive delivery systems are highly desirable to regulate glycemia with minimal patient effort and improve the quality of life for diabetic patients. 12, 13 In this review, we will focus on the different stimuli‐responsive systems for diabetic therapeutic delivery, including pH‐responsive, glucose‐responsive, and external physical trigger

Poloxamers. The ideal drug delivery system is the one in which the drug delivery profile is able to respond to metabolic states and/or physiological variations (Bawa et al., 2009).

• Stimuli are exogenous (light) or endogenous triggers in the tumor microenvironment. 2019-01-01 · Physical stimuli-responsive vesicles in drug delivery: Beyond liposomes and polymersomes 1. Introduction. The aim of drug delivery is to increase therapeutic efficacy. Drug delivery vesicles can aid in this 2. Triggered drug delivery using vesicles.